Rigor and Reproducibility in Analysis of Vascular Calcification.
نویسندگان
چکیده
Clinical and preclinical studies of cardiovascular calcification often require interpretation of images from histopathology, computed tomography, intravascular ultrasound, and positron emission tomography. To avoid potential pitfalls in biological inferences, investigators should know what happens to data in image processing algorithms, the limitations of cross-sectional images in studying mechanostability, and how smoothing algorithms can mask partial-volume artifacts in positron emission tomography.
منابع مشابه
Evaluation of Vitamin D Level and its Correlation to Vascular Calcification in Hemodialysis Patients
Introduction: Compared with the general population, hemodialysis patients are at increased risk of vascular calcification, which in turn is associated with an increased risk of mortality. Regarding the role of vitamin D in bone formation, regulation of calcium, phosphate and iPTH level and correlation of these variables in survival, this study was performed to evaluate the vitamin D serum level...
متن کاملMicroRNA-297a regulates vascular calcification by targeting fibroblast growth factor 23
Objective(s): Vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. MiRNAs have been shown to be involved in many normal biological functions as well as diseases; however, their role in vascular calcification has not received much attention. Materials and Methods: In the current study, we built a vascular calcification rat mode...
متن کاملInflammation and Vascular Calcification Causing Effects of Oxidized HDL are Attenuated by Adiponectin in Human Vascular Smooth Muscle Cells
The role of oxidized high-density lipoprotein (oxHDL) and the protective effects of adiponectin in terms of vascular calcification is not well established. This study was conducted to investigate the effects of oxHDL with regards to inflammation and vascular calcification and to determine the protective role of adiponectin in attenuating the detrimental effects of oxHDL. Cell viability, mineral...
متن کاملThe Utility of Alizarin Red S Staining in Detection of Vascular Calcification Due to Monckeberg's Sclerosis
Purpose: This study designed to introduce Alizarin red S staining instead of Hematoxylin and Eosin staining in diagnosis of calcification of the paraffin sections. Materials and Methods: Uterine paraffin sections belong to the 20 women aged 53±4, endured hysterectomy stained with H&E and ARS staining. For H&E, the sections were treated with Mayer's hematoxylin (pH 2.3) for 5 min and with Eosin...
متن کاملEffect of Oxidized Low Density Lipoprotein on the Expression of Runx2 and SPARC Genes in Vascular Smooth Muscle Cells
Background: Vascular calcification is an important stage in atherosclerosis. During this stage, vascular smooth muscle cells (VSMC) synthesize many osteogenic factors such as osteonectin (encoded by SPARC). Oxidative stress plays a critical role in atherosclerosis progression, and its accumulation in the vascular wall stimulates the development of atherosclerosis and vascular calcification. The...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation research
دوره 120 8 شماره
صفحات -
تاریخ انتشار 2017